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Doctors Leonard Hofstadter & Sheldon Cooper (Johnny Galecki & Jim Parsons) are brilliant physicists – masterminds of their CalTech laboratories, but socially challenged in the non-theoretical real world. Enter beautiful, street-smart neighbor, the actress/waitress Penny (Kaley Cuoco), who aims to teach them a thing or two about life. Despite their on-again, off-again relationship in the past, Leonard believes he's found true love with Penny. Even Sheldon has grown comfortable with a female companion, entering into a signed "Relationship Agreement" with neurobiologist Amy Farrah Fowler (Mayim Bialik). In their free time, Leonard and Sheldon continue to enjoy weekly trips to the comic book store and fantasy role-playing games with their ever-expanding universe of friends, including fellow scientists Rajesh Koothrappali (Kunal Nayyar), Howard Wolowitz (Simon Helberg), and Howard's microbiologist wife, Bernadette (Melissa Rauch).]]>

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Prepare to enter the eighth dimension of television's perpetual laughter continuum as THE BIG BANG THEORY boldly crosses the frontiers of science and comedy. Doctors Hofstadter & Cooper remain socially challenged, but the two genius roommates and their friends always produce hilarious results. With Leonard finally engaged to girl-across-the-hall Penny after countless proposals, the possibilities for happiness seem endless…while the probability for laughs is a foregone conclusion. What's unknown is how this might impact the ironclad "Roommate Agreement" he's entered into with Sheldon. Add to this, Sheldon's uncomfortably close relationship with neurobiologist Amy Farrah Fowler, Koothrappali's newfound ability to talk to and date women, and Howard and Bernadette's solution to an in-house caretaker (Stuart Bloom) for the always outspoken Mrs. Wolowitz, and the worlds of science and sitcom are about to hilariously collide!]]>